VSEs for Lentivirus
At Virica Biotech, our proprietary Viral Sensitizers (VSE™) enhance lentivirus production and transduction by temporarily suppressing cellular defenses that limit viral yield and transduction efficiency. Our lentivirus-specific VSEs offer a scalable plug-and-play solution that empowers researchers and biomanufacturers to improve yield, maximize transduction efficiency, and accelerate cell and gene therapy development.
Optimizing Lentivirus Production
Maximize your lentivirus functional titer by 2x-4x with our LV-specific VSE cell enhancers. The cell enhancers are curated for optimal performance with adherent HEK293T and suspension HEK293 cells. Our enhancers are simple media additives that seamlessly integrate into your workflow, substantially increasing lentivirus yield without disrupting your current process.
Benefits:
- Up to 2x-4x increase in functional lentivirus titer (TU/mL)
- Simple media additive that is easy to incorporate
- Accelerates lentivirus manufacturing
- Reduces lentiviral production costs
- Improves scalability
Addition of VSE™ to both adherent and suspension transfection-based culture systems enhances functional lentivirus production by up to 4-fold.
Addition of VSE™ to both adherent and suspension transfection-based culture systems enhances functional lentivirus production by up to 4-fold.
Maximizing Lentivirus Transduction
Increase your lentiviral transduction efficiency by >2x with our transduction enhancers. Our lentiviral transduction enhancers are curated for optimal performance across primary cells (T-cells, HSCs, MSCs). Our enhancers are simple media additives that seamlessly integrate into your workflow, substantially increasing transduction efficiency without disrupting your current process.
Benefits:
- >2x increase in transduction efficiency without impacting cell viability
- Lowers MOI to reduce lentiviral dose requirements
- Simple media additive that is easy to incorporate
- Accelerates lentiviral-based cell therapy development
- Reduces production costs
- Improves scalability
Addition of VSE™ to T-cells prior to transduction with lentivirus improved transduction efficiency >2x without impacting cell viability. Results were repeated across multiple independent donors (data not shown).