Virica Advantage

Virica’s platform technology helps achieve key goals in vaccine and cell & gene therapy manufacturing

Cost Reduction

Through improved manufacturing productivity and efficiency

Simplification

Platform agnostic solution that easily integrates into your process without disruption

De-risk

Robust, scalable platform with dedicated support

Integrated Service and Product Offering to Maximize Success

Virica deploys decades of cell enhancer expertise and proprietary High-Throughput Virology (HTV™) workflows to help clients achieve manufacturing productivity, efficiency and scale using VSEs.

What’s in Our Toolbox?

Virica leverages powerful tools and services to identify optimal VSEs and rapidly increase viral vector production.

High Throughput Virology (HTV™)Workflow

  • Proprietary screening panels, to rapidly identify compounds
  • Leverages Virica’s extensive compound library

Design of Experiments (DoE) Methodology

  • Streamline assay development and screening
  • Rapidly identify optimized scale-up and production parameters

Analytical Services

  • Residual testing
  • Viral quantification
  • Transduction Assay

Bioprocess Modelling

  • Model different scenarios specific to your process
  • Identify key cost drivers
  • Proprietary screening panels, to rapidly identify compounds
  • Leverages Virica’s extensive compound library
  • Streamline assay development and screening
  • Rapidly identify optimized scale-up and production parameters
  • Residual testing
  • Viral quantification
  • Transduction Assay
  • Model different scenarios specific to your process
  • Identify key cost drivers

Ongoing Support Services

Virica offers a range of services to support the integration of VSEs into your process and scale-up. Our offerings include analytical services, regulatory filing support, and scale-up or tech transfer assistance, designed to help you at every stage of development.

Analytical and Regulatory Support

Virica provides all the support needed to help meet the necessary regulatory requirements for the
incorporation of our VSEs into your processes.

Virica has toxicological information on key VSEs to support regulatory filings, if required.

GMP Enabled

  • GMP grade available
  • Filing support
  • Material traceability
  • Residual studies
  • Toxicology Studies
  • DMFs available

Top Panel: Calibration data showing limit of detection for our VSE is in the femtomole range using MRM.
Bottom Panel: (A) Control MVA production sample spiked with VSEs prior to MRM-Mass Spectrometry (B)
Purified MVA sample grown with VSEs shows no trace following MRM-Mass Spectrometry

Optimize Your Way

Clients have the flexibility of in-house or Virica-led implementation of VSEs. The results are VSE formulations tailored to your unique application, with ongoing support to integrate VSEs and achieve their benefits.

Virica’s Development Services

Client outsources production optimization to Virica and we identify optimal VSEs in-house using our proprietary high-throughput assays and DoE methodologies. By outsourcing testing and formulation, the client benefits from decades of expertise, rapid and flexible production parameter optimization, deeper insights into their production process and a ~30% time reduction. This approach frees up your bandwidth, takes advantage of our extensive expertise and gets you faster results.

Client-Driven Development

You can develop a tailor-made formulation of our VSEs by testing them at your own facilities. We send you a prioritized subset of our VSEs and provide you with dedicated support throughout, from designing experiments to developing an optimal VSE formulation. We provide support to meet the necessary manufacturing-related regulatory requirements to incorporate VSEs into your process and realize its benefits.