VSEs for AAV Production

At Virica Biotech, our proprietary Viral Sensitizer (VSE™) enhancers increase AAV manufacturing efficiency by transiently dampening innate cellular defenses. Our plug-and-play AAV enhancers empower researchers and manufacturers to achieve significant increases in AAV yield and rapid production optimization, accelerating timelines and cutting costs.

VSEs for AAV Production​

Increase your AAV titer up to 5x with our AAV-specific VSE cell enhancers. Compatible with various AAV serotypes and HEK-based cell lines, our enhancers are simple media additives that seamlessly integrate into your workflow as ancillary material, substantially increasing AAV yield without disrupting your current process.

Benefits:

  • Up to 5x increase in AAV genomic titer (vg/mL)
  • Robust yield enhancement across multiple AAV serotypes
  • Simple media additive that is easy to incorporate
  • Accelerates AAV viral vector-based therapeutic pipeline development
  • Reduces production costs
  • Improves scalability
Addition of VSE™ to suspension proprietary cells shows enhancement across multiple AAV serotypes.
Combinations of VSE™ showed additive effects in AAV yield enhancement due to non-overlapping mechanisms of action.
VSE™ effect is scalable to larger scale production volumes, showing similar AAV yield enhancements between shake flask and bioreactor scale.

Ready to Maximize AAV Yields?

Connect with our team and discover how VSEs can seamlessly enhance AAV production without disrupting existing vector manufacturing processes.