Technology

Virica’s Viral Sensitizers (VSETM) are small-molecule media additives that significantly enhance upstream productivity without impacting your process. Using our proprietary High Throughput Virology (HTVTM) platform and Design of Experiments (DoE) services, we empower cell and gene therapy and vaccine manufacturers to maximize viral production, accelerate timelines and lower costs, all in one comprehensive approach.

How Do Viral Sensitizers (VSETM) Work?

VSEs are small molecules that enhance manufacturing cells by targeting key signaling pathways and temporarily dampening cellular defenses that reduce viral yield and quality. This allows the virus to infect, transduce and replicate better. VSEs are simple-free media additives that improve viral vector manufacturing efficiency and lower costs.

Virica’s proprietary High Throughput Virology (HTVTM) platform ensures purpose-built and optimal VSEs for various cell lines and virus combinations.

MOA

VSEs integrate into upstream processes as ancillary material

VSEs are ancillary materials that are administered at or around the time of infection or transfection to attenuate innate cellular defenses. VSEs integrate into your process without disruption. VSEs are rapidly metabolized by producer cells (≤24hrs) and are cleared before downstream processing of final products by standard purification methods.

Explore our Application-Specific VSEs:

Maximizing AAV Production
Enhancing Lentivirus Manufacturing
Increasing Vaccine Production
Maximizing AAV Production
Enhancing Lentivirus Manufacturing
Increasing Vaccine Production

Optimize Your Way

Clients have the flexibility of in-house or Virica-led implementation of VSEs. The results are VSE formulations tailored to your unique application, with ongoing support to integrate VSEs and achieve their benefits.

Virica’s Development Services

Client outsources production optimization to Virica and we identify optimal VSEs in-house using our proprietary high-throughput assays and DoE methodologies. By outsourcing testing and formulation, the client benefits from decades of expertise, rapid and flexible production parameter optimization, deeper insights into their production process and a ~30% time reduction. This approach frees up your bandwidth, takes advantage of our extensive expertise and gets you faster results.

Client-Driven Development

You can develop a tailor-made formulation of our VSEs by testing them at your own facilities. We send you a prioritized subset of our VSEs and provide you with dedicated support throughout, from designing experiments to developing an optimal VSE formulation. We provide support to meet the necessary manufacturing-related regulatory requirements to incorporate VSEs into your process and realize its benefits.