The Impact of Antiviral Defenses in Viral Vector Production

The impact of innate cellular defenses has emerged as a crucial area of investigation in viral vector manufacturing. Several recent publications have highlighted that the cell’s natural response to the introduction of foreign genetic material can trigger defenses that hinder viral production efficiency. Although there have been many approaches to circumvent these barriers, the antiviral network’s complexity is not an easy limitation to overcome. Learn more about the cellular defenses present in current manufacturing  cell lines and strategies to mitigate their impact on viral vector production in this whitepaper.