Increasing AAV8 Yields in the iCELLis™ Nano Bioreactor Using VSE™ Technology

Discover how a simple upstream additive can double AAV yields and reduce production costs, without overhauling your platform. This whitepaper highlights Virica’s collaboration with Cytiva, demonstrating how Viral Sensitizer (VSE™) technology enhances AAV8 production in the iCELLis™ Nano fixed-bed bioreactor. Using a stepwise approach, from high-throughput screening to small-scale validation and bioreactor-scale testing, the team developed a VSE formulation that achieved an average 2-fold increase in yield. The results confirm that VSEs integrate seamlessly into adherent HEK293-based processes, offering a scalable and effective solution. If you’re facing upstream bottlenecks in AAV manufacturing, this whitepaper delivers actionable insights to improve both productivity and process economics.