High-Throughput Screening of Next Generation Small Molecule Enhancers and Process Automation in Cloud-Connected Bioreactors

Poster showcases a collaboration between Virica Biotech and Culture Biosciences to evaluate next-generation Viral Sensitizer Enhancers (VSE™) using high-throughput screening and cloud-connected bioreactors. Virica identified an expanded library of small molecules that led to a 2- 5x enhancement in AAV production in HEK293 suspension cells. Two lead VSEs were validated in Culture’s 250 mL bioreactors, delivering consistent 2–5-fold yield improvements. This combined platform enables rapid screening, scalable process optimization, and real-time data monitoring for advanced gene therapy manufacturing.