Evaluation of Small Molecule Antagonists of Cellular Innate Immunity for T-cell Manufacturing

Poster presents Virica’s evaluation of Viral Sensitizer Enhancers (VSE™) for improving lentiviral vector manufacturing and T-cell transduction efficiency. VSEs were shown to significantly increase lentiviral titers in both inducible and transfection-based production systems, with up to a 13.4-fold yield improvement when combined with standard additives. Importantly, pre-treating T-cells with VSEs more than doubled transduction efficiency without compromising cell viability. These findings highlight the potential of VSEs to overcome innate immune barriers and streamline the production of high-quality viral vectors for T-cell therapeutics.