Bioprocess Modelling of Upstream Viral Vector Production

Virica leverages bioprocess modelling to demonstrate the substantial economic and environmental benefits achievable through the application of Viral Sensitizer (VSE™) technology, specifically designed to enhance upstream viral vector production yields. VSE cell enhancers significantly increase yields (up to 7.4-fold for lentiviruses and 2-fold or more for AAV vectors). Economic modelling illustrates that even moderate yield enhancements (e.g., 2-fold) can drastically reduce annual COGS by 33% through the reduction of required bioreactor volumes or quantities, simultaneously lowering environmental impacts such as plastic and water usage. Virica’s approach offers optimal VSEs that easily integrated into existing manufacturing workflows without disruption, positioning manufacturers to economically meet rising demand for viral vectors essential in cell and gene therapies.