A Novel Approach to Enhancing Viral Vector Manufacturing Using Small Molecules

Virica’s small molecule Viral Sensitizer (VSE™) enhances viral vector production yields by reducing innate cellular defenses, a critical and often overlooked manufacturing barrier. Our data shows VSEs significantly increase lentivirus (7.4-fold), AAV2 (over 2-fold), and MVA (up to 10-fold) yields. VSEs are broadly applicable, easily integrate into existing processes as ancillary material without process disruption and rapidly degrade, ensuring no residual impact. Virica offers application-specific VSEs that optimize productivity, scalability, and cost-efficiency in viral vector manufacturing.