Vaccine Vector Production Enhancement Using Small Molecule VSE™

Virica’s Viral Sensitizers (VSE™) enhance vaccine manufacturing by significantly increasing viral yields across multiple platforms, including influenza, measles, and MVA production. Using BioSolve Process modeling, the study demonstrates that even modest yield improvements (e.g., 1.8x) can result in substantial reductions in upstream production costs, batch numbers, and environmental impact. Tested in both small-scale cultures and iCELLis® Nano bioreactors, VSEs delivered up to 7-fold increases in viral yield and up to 4-fold at scale. These results position VSEs as a scalable, easy-to-integrate solution for improving vaccine supply and affordability globally.