Optimizing AAV Production Efficiency: A Scalable Approach Using Small Molecule Viral Sensitizers

This poster showcases how Virica’s Viral Sensitizers (VSE™) tackle innate cellular defenses to deliver major gains in AAV manufacturing. Using high-throughput screening with Design of Experiments (DoE), Virica identified top-performing molecules that boosted AAV yields more than 2.5-fold at bioreactor scale and up to 6-fold in functional titer. In ReiThera’s ReiCell-AAV platform, tailored formulations drove over 4-fold improvements at 2L scale. Cost modeling confirmed these yield gains can meaningfully cut per-dose costs, making VSEs a scalable, plug-and-play solution for more efficient and affordable gene therapies.