Enhancing Lentiviral Transduction Efficiency and Reducing MOI in Therapeutically Relevant Cell Types Using Small Molecule Viral Sensitizers

This poster shows how Virica’s Viral Sensitizers (VSE™) boost lentiviral transduction efficiency in T-cells, NK cells, MSCs, and HSCs, driving up to 2.8-fold improvements. By reaching high transduction levels at lower MOIs, VSEs cut vector use, improve scalability, and reduce variability. BioSolve modeling confirms the impact: lowering MOI by 2x can slash manufacturing costs per dose by up to 35%. The result is a plug-and-play solution that makes cell therapy production more efficient, scalable, and cost-effective.