{"id":4079,"date":"2025-07-17T07:54:52","date_gmt":"2025-07-17T11:54:52","guid":{"rendered":"https:\/\/www.viricabiotech.com\/staging\/?post_type=avada_portfolio&#038;p=4079"},"modified":"2025-07-17T07:54:52","modified_gmt":"2025-07-17T11:54:52","slug":"optimization-of-zika-vaccine-production-using-small-molecule-viral-sensitizers-to-enhance-yields","status":"publish","type":"avada_portfolio","link":"https:\/\/www.viricabiotech.com\/staging\/resources\/optimization-of-zika-vaccine-production-using-small-molecule-viral-sensitizers-to-enhance-yields\/","title":{"rendered":"Optimization of Zika Vaccine Production Using Small-Molecule Viral Sensitizers to Enhance Yields"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><div>Max\u202fPlanck Institute\u2019s latest publication combines Design of Experiments\u202f(DoE), synergy calculations, generative\u2011AI\u2011designed scale\u2011down reactors, and cost modelling to show how Virica\u2019s GMP\u2011ready, small molecule Viral Sensitizers\u202f(VSE\u2122) serve as a simple media additive that significantly boosts Zika\u2011vaccine production. A single additive step can translate into multi-fold productivity gains and double-digit cost savings, an attractive route to faster, more economical, pandemic-ready vaccine manufacturing.<\/div>\n<div>Key takeaways:<\/div>\n<ul>\n<li>Titer increases up to 7X across all three cell lines after a single VSE addition<\/li>\n<li>Further synergistic titer increases after multi-dose VSE evaluation using DoE<\/li>\n<li>Titer increases up to 8X in 3D-printed scale-down mimics of 200L or 2000L Xcellerex bioreactors<\/li>\n<li>Up to 61% reduction in cost per dose for a 3X yield increase at 2000L<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4080,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"portfolio_category":[82],"portfolio_skills":[],"portfolio_tags":[69],"class_list":["post-4079","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-article","portfolio_tags-vaccines"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/4079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/comments?post=4079"}],"version-history":[{"count":1,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/4079\/revisions"}],"predecessor-version":[{"id":4082,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/4079\/revisions\/4082"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/media\/4080"}],"wp:attachment":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/media?parent=4079"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_category?post=4079"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_skills?post=4079"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_tags?post=4079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}