{"id":3595,"date":"2025-04-20T13:01:59","date_gmt":"2025-04-20T17:01:59","guid":{"rendered":"https:\/\/www.viricabiotech.com\/staging\/?post_type=avada_portfolio&#038;p=3595"},"modified":"2025-04-29T20:17:43","modified_gmt":"2025-04-30T00:17:43","slug":"a-novel-approach-to-enhancing-viral-vector-manufacturing-using-small-molecules","status":"publish","type":"avada_portfolio","link":"https:\/\/www.viricabiotech.com\/staging\/resources\/a-novel-approach-to-enhancing-viral-vector-manufacturing-using-small-molecules\/","title":{"rendered":"A Novel Approach to Enhancing Viral Vector Manufacturing Using Small Molecules"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>Virica&#8217;s small molecule Viral Sensitizer (VSE\u2122) enhances viral vector production yields by reducing innate cellular defenses, a critical and often overlooked manufacturing barrier. Our data shows VSEs significantly increase lentivirus (7.4-fold), AAV2 (over 2-fold), and MVA (up to 10-fold) yields. VSEs are broadly applicable, easily integrate into existing processes as ancillary material without process disruption and rapidly degrade, ensuring no residual impact. Virica offers application-specific VSEs that optimize productivity, scalability, and cost-efficiency in viral vector manufacturing.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":2538,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"portfolio_category":[72],"portfolio_skills":[],"portfolio_tags":[70],"class_list":["post-3595","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-poster","portfolio_tags-cell-gene-therapies"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/comments?post=3595"}],"version-history":[{"count":2,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3595\/revisions"}],"predecessor-version":[{"id":3888,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3595\/revisions\/3888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/media\/2538"}],"wp:attachment":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/media?parent=3595"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_category?post=3595"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_skills?post=3595"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_tags?post=3595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}