{"id":3589,"date":"2025-04-20T12:54:49","date_gmt":"2025-04-20T16:54:49","guid":{"rendered":"https:\/\/www.viricabiotech.com\/staging\/?post_type=avada_portfolio&#038;p=3589"},"modified":"2025-04-29T20:18:42","modified_gmt":"2025-04-30T00:18:42","slug":"increasing-vaccine-production-yields-using-small-molecules","status":"publish","type":"avada_portfolio","link":"https:\/\/www.viricabiotech.com\/staging\/resources\/increasing-vaccine-production-yields-using-small-molecules\/","title":{"rendered":"Increasing Vaccine Production Yields Using Small Molecules"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>Virica\u2019s proprietary small molecule Viral Sensitizers (VSE\u2122) significantly enhance vaccine production yields by temporarily suppressing innate cellular defenses in production cell lines. Our collaborations with IDT Biologika and Max Planck Institute demonstrate robust VSE-driven yield increase across different viral constructs, including Yellow-Fever and Modified Vaccinia Ankara (MVA) vaccines, achieving up to a 7-fold increase in infectious virus titer. Bioprocess modeling shows that even modest improvements in viral yields substantially lower manufacturing costs per dose, enhancing the economic viability and scalability of vaccine production.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":2801,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"portfolio_category":[72],"portfolio_skills":[],"portfolio_tags":[69],"class_list":["post-3589","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-poster","portfolio_tags-vaccines"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/comments?post=3589"}],"version-history":[{"count":2,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3589\/revisions"}],"predecessor-version":[{"id":3890,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3589\/revisions\/3890"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/media\/2801"}],"wp:attachment":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/media?parent=3589"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_category?post=3589"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_skills?post=3589"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_tags?post=3589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}