{"id":3587,"date":"2025-04-20T12:51:20","date_gmt":"2025-04-20T16:51:20","guid":{"rendered":"https:\/\/www.viricabiotech.com\/staging\/?post_type=avada_portfolio&#038;p=3587"},"modified":"2025-04-29T20:19:32","modified_gmt":"2025-04-30T00:19:32","slug":"modeling-benefits-of-viral-sensitizers-to-increase-virus-production","status":"publish","type":"avada_portfolio","link":"https:\/\/www.viricabiotech.com\/staging\/resources\/modeling-benefits-of-viral-sensitizers-to-increase-virus-production\/","title":{"rendered":"Modeling Benefits of Viral Sensitizers to Increase Virus Production"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>Virica&#8217;s proprietary small molecule Viral Sensitizers (VSE\u2122) improve virus manufacturing productivity by transiently reducing innate cellular defenses within production cell lines. These innate cellular responses limit viral yield, making them a significant yet underappreciated manufacturing barrier. Using bioprocess modeling, the poster demonstrates that even modest increases in viral yield with VSE\u2122 can significantly reduce manufacturing costs per dose, thereby enhancing vaccine affordability and accessibility. The efficacy of VSE\u2122 was validated through experiments across various cell lines and viral constructs, including influenza, measles, and yellow fever, consistently resulting in multi-fold increases in viral titer.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":2799,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"portfolio_category":[72],"portfolio_skills":[],"portfolio_tags":[69],"class_list":["post-3587","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-poster","portfolio_tags-vaccines"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/comments?post=3587"}],"version-history":[{"count":1,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3587\/revisions"}],"predecessor-version":[{"id":3588,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/avada_portfolio\/3587\/revisions\/3588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/media\/2799"}],"wp:attachment":[{"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/media?parent=3587"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_category?post=3587"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_skills?post=3587"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/www.viricabiotech.com\/staging\/wp-json\/wp\/v2\/portfolio_tags?post=3587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}